What is the current starting age for colorectal cancer screening according to USPSTF guidelines?

• A. 50
• B. 45
• C. 40
• D. 55

Answer: (B)

Starting screening at age 45 for average‑risk individuals is the current guidance. This change, made by the USPSTF in 2021, reflects rising colorectal cancer rates in people under 50 and evidence that detecting cancers earlier improves outcomes. The plan is to continue routine screening through age 75, with decisions beyond that age individualized. In practice, this means people who are average risk should begin screening at 45 rather than 50, using the standard options (colonoscopy every 10 years, stool-based tests yearly, or other endorsed methods) and choose the modality and interval based on their risk and preferences. The shift from 50 to 45 is the key point to remember.