What is a key cervical cancer screening strategy according to USPSTF?

• A. Screening with cytology (Pap smear) with HPV testing as appropriate
• B. HPV testing alone every 5 years
• C. Pelvic exam alone annually
• D. Cytology alone every year

Answer: (A)

Cervical cancer screening is most effective when you combine a test that detects cellular changes with a test that detects the virus that often causes those changes. The Pap smear screens for abnormalities in cervical cells, while HPV testing looks for high-risk human papillomavirus infections. USPSTF endorses this combined approach as a key strategy for average-risk adults, typically 30 to 65 years old, with co-testing performed every 5 years. This integrated method improves sensitivity for detecting precancerous changes compared with either test alone. Pelvic exams by themselves are not a valid screening method for cervical cancer, and cytology alone every year is more frequent than current guidelines recommend. HPV testing alone every 5 years is a valid alternative in some guideline options, but the description that includes both tests reflects the comprehensive screening approach emphasized by USPSTF.