What grade does the USPSTF assign to colorectal cancer screening for adults aged 50 to 75?

• A. Grade A
• B. Grade B
• C. Grade C
• D. Grade D

Answer: (A)

Grade A means there is high certainty that the net benefit of colorectal cancer screening for average-risk adults aged 50 to 75 is substantial, so the service should be offered. This reflects strong, evidence-based support from multiple studies showing that screening reduces both the incidence and mortality of colorectal cancer, with harms that are generally outweighed by the benefits. The recommended options include colonoscopy every 10 years, flexible sigmoidoscopy every 5 years plus stool testing, CT colonography every 5 years, or annual stool-based tests, and the broad consensus across these modalities contributes to the Grade A designation.