What grade did the USPSTF assign to the HIV preexposure prophylaxis recommendation?

• A. Grade B
• B. Grade C
• C. Grade D
• D. Grade A

Answer: (D)

Understanding the grade reflects how strong the evidence is for a preventive service and how big the benefit is. For HIV preexposure prophylaxis, the USPSTF assigns a Grade A because there is high certainty that the net benefit is substantial for adults at risk of HIV infection. This means clinicians should offer or provide PrEP to patients who have substantial risk, after a discussion of benefits, risks, and adherence considerations, with appropriate follow-up and monitoring. The option that suggests a lower benefit or no benefit doesn’t fit the strength of the evidence and the demonstrated reduction in HIV acquisition with PrEP. Therefore, the correct grade is A.